The lymphatic vasculature in disease.
Identifieur interne : 004A56 ( Main/Exploration ); précédent : 004A55; suivant : 004A57The lymphatic vasculature in disease.
Auteurs : Kari Alitalo [Finlande]Source :
- Nature medicine [ 1546-170X ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Humains, Inflammation (anatomopathologie), Inflammation (physiopathologie), Lymphangiogenèse (physiologie), Lymphe (physiologie), Lymphoedème (anatomopathologie), Lymphoedème (physiopathologie), Métastase lymphatique (anatomopathologie), Métastase lymphatique (physiopathologie), Protéines et peptides de signalisation intercellulaire (métabolisme), Récepteurs à activité tyrosine kinase (métabolisme), Système immunitaire (physiologie), Système lymphatique (anatomopathologie), Système lymphatique (physiologie), Système lymphatique (physiopathologie), Transplantation d'organe, Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (physiologie), Vaisseaux lymphatiques (physiopathologie).
- MESH :
- anatomopathologie : Inflammation, Lymphoedème, Métastase lymphatique, Système lymphatique, Vaisseaux lymphatiques.
- métabolisme : Protéines et peptides de signalisation intercellulaire, Récepteurs à activité tyrosine kinase.
- physiologie : Lymphangiogenèse, Lymphe, Système immunitaire, Système lymphatique, Vaisseaux lymphatiques.
- physiopathologie : Inflammation, Lymphoedème, Métastase lymphatique, Système lymphatique, Vaisseaux lymphatiques.
- Animaux, Humains, Transplantation d'organe.
English descriptors
- KwdEn :
- Animals, Humans, Immune System (physiology), Inflammation (pathology), Inflammation (physiopathology), Intercellular Signaling Peptides and Proteins (metabolism), Lymph (physiology), Lymphangiogenesis (physiology), Lymphatic Metastasis (pathology), Lymphatic Metastasis (physiopathology), Lymphatic System (pathology), Lymphatic System (physiology), Lymphatic System (physiopathology), Lymphatic Vessels (pathology), Lymphatic Vessels (physiology), Lymphatic Vessels (physiopathology), Lymphedema (pathology), Lymphedema (physiopathology), Organ Transplantation, Receptor Protein-Tyrosine Kinases (metabolism).
- MESH :
- chemical , metabolism : Intercellular Signaling Peptides and Proteins, Receptor Protein-Tyrosine Kinases.
- pathology : Inflammation, Lymphatic Metastasis, Lymphatic System, Lymphatic Vessels, Lymphedema.
- physiology : Immune System, Lymph, Lymphangiogenesis, Lymphatic System, Lymphatic Vessels.
- physiopathology : Inflammation, Lymphatic Metastasis, Lymphatic System, Lymphatic Vessels, Lymphedema.
- Animals, Humans, Organ Transplantation.
Abstract
Blood vessels form a closed circulatory system, whereas lymphatic vessels form a one-way conduit for tissue fluid and leukocytes. In most vertebrates, the main function of lymphatic vessels is to collect excess protein-rich fluid that has extravasated from blood vessels and transport it back into the blood circulation. Lymphatic vessels have an important immune surveillance function, as they import various antigens and activated antigen-presenting cells into the lymph nodes and export immune effector cells and humoral response factors into the blood circulation. Defects in lymphatic function can lead to lymph accumulation in tissues, dampened immune responses, connective tissue and fat accumulation, and tissue swelling known as lymphedema. This review highlights the most recent developments in lymphatic biology and how the lymphatic system contributes to the pathogenesis of various diseases involving immune and inflammatory responses and its role in disseminating tumor cells.
DOI: 10.1038/nm.2545
PubMed: 22064427
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002401
- to stream PubMed, to step Curation: 002401
- to stream PubMed, to step Checkpoint: 002401
- to stream Ncbi, to step Merge: 004799
- to stream Ncbi, to step Curation: 004799
- to stream Ncbi, to step Checkpoint: 004799
- to stream Main, to step Merge: 004A88
- to stream Main, to step Curation: 004A56
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The lymphatic vasculature in disease.</title><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation wicri:level="1"><nlm:affiliation>Molecular/Cancer Biology Program, Faculty of Medicine, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland. kari.alitalo@helsinki.fi</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Program, Faculty of Medicine, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:22064427</idno><idno type="pmid">22064427</idno><idno type="doi">10.1038/nm.2545</idno><idno type="wicri:Area/PubMed/Corpus">002401</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002401</idno><idno type="wicri:Area/PubMed/Curation">002401</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002401</idno><idno type="wicri:Area/PubMed/Checkpoint">002401</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002401</idno><idno type="wicri:Area/Ncbi/Merge">004799</idno><idno type="wicri:Area/Ncbi/Curation">004799</idno><idno type="wicri:Area/Ncbi/Checkpoint">004799</idno><idno type="wicri:Area/Main/Merge">004A88</idno><idno type="wicri:Area/Main/Curation">004A56</idno><idno type="wicri:Area/Main/Exploration">004A56</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The lymphatic vasculature in disease.</title><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation wicri:level="1"><nlm:affiliation>Molecular/Cancer Biology Program, Faculty of Medicine, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland. kari.alitalo@helsinki.fi</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Program, Faculty of Medicine, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author></analytic><series><title level="j">Nature medicine</title><idno type="eISSN">1546-170X</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Humans</term><term>Immune System (physiology)</term><term>Inflammation (pathology)</term><term>Inflammation (physiopathology)</term><term>Intercellular Signaling Peptides and Proteins (metabolism)</term><term>Lymph (physiology)</term><term>Lymphangiogenesis (physiology)</term><term>Lymphatic Metastasis (pathology)</term><term>Lymphatic Metastasis (physiopathology)</term><term>Lymphatic System (pathology)</term><term>Lymphatic System (physiology)</term><term>Lymphatic System (physiopathology)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphatic Vessels (physiology)</term><term>Lymphatic Vessels (physiopathology)</term><term>Lymphedema (pathology)</term><term>Lymphedema (physiopathology)</term><term>Organ Transplantation</term><term>Receptor Protein-Tyrosine Kinases (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Inflammation (anatomopathologie)</term><term>Inflammation (physiopathologie)</term><term>Lymphangiogenèse (physiologie)</term><term>Lymphe (physiologie)</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (physiopathologie)</term><term>Métastase lymphatique (anatomopathologie)</term><term>Métastase lymphatique (physiopathologie)</term><term>Protéines et peptides de signalisation intercellulaire (métabolisme)</term><term>Récepteurs à activité tyrosine kinase (métabolisme)</term><term>Système immunitaire (physiologie)</term><term>Système lymphatique (anatomopathologie)</term><term>Système lymphatique (physiologie)</term><term>Système lymphatique (physiopathologie)</term><term>Transplantation d'organe</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (physiologie)</term><term>Vaisseaux lymphatiques (physiopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Intercellular Signaling Peptides and Proteins</term><term>Receptor Protein-Tyrosine Kinases</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Inflammation</term><term>Lymphoedème</term><term>Métastase lymphatique</term><term>Système lymphatique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines et peptides de signalisation intercellulaire</term><term>Récepteurs à activité tyrosine kinase</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Inflammation</term><term>Lymphatic Metastasis</term><term>Lymphatic System</term><term>Lymphatic Vessels</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphangiogenèse</term><term>Lymphe</term><term>Système immunitaire</term><term>Système lymphatique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Immune System</term><term>Lymph</term><term>Lymphangiogenesis</term><term>Lymphatic System</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Inflammation</term><term>Lymphoedème</term><term>Métastase lymphatique</term><term>Système lymphatique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Inflammation</term><term>Lymphatic Metastasis</term><term>Lymphatic System</term><term>Lymphatic Vessels</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Organ Transplantation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Transplantation d'organe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Blood vessels form a closed circulatory system, whereas lymphatic vessels form a one-way conduit for tissue fluid and leukocytes. In most vertebrates, the main function of lymphatic vessels is to collect excess protein-rich fluid that has extravasated from blood vessels and transport it back into the blood circulation. Lymphatic vessels have an important immune surveillance function, as they import various antigens and activated antigen-presenting cells into the lymph nodes and export immune effector cells and humoral response factors into the blood circulation. Defects in lymphatic function can lead to lymph accumulation in tissues, dampened immune responses, connective tissue and fat accumulation, and tissue swelling known as lymphedema. This review highlights the most recent developments in lymphatic biology and how the lymphatic system contributes to the pathogenesis of various diseases involving immune and inflammatory responses and its role in disseminating tumor cells.</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><country name="Finlande"><region name="Uusimaa"><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004A56 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004A56 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:22064427
|texte= The lymphatic vasculature in disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22064427" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |